Apr 5, 2024 Our review paper about stem cell has been published in EnM
Our review article titled 'Scaling Insulin-Producing Cells by Multiple Strategies' has been published in Endocrinology and Metabolism. https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2023.1910. In the article, we discuss the current challenges in scaling up stem cell-derived cell products.
Apr 4, 2024 Seminar in JDRF Beta Cell Replacement Consortium
Dr. Yoshihara gave a talk entitled “Functional selection, Mass Production and immune-evasion of stem cell derived islets” at the JDRF Beta Cell Replacement Consortium. During the talk, Dr. Yoshihara discussed the current challenges of stem cell therapy in treating diabetes.
Apr 1, 2024 NIH R01 Award
Our lab awarded NIH R01 Grant for Diabetes Stem Cell Therapy Research.
Feb 22, 2024 Editorial in Antioxidants & Redox Signaling
Dr. Yoshihara's editorial paper, titled “Redoxisome Update: TRX and TXNIP/TBP2-Dependent Regulation of NLRP-1/NLRP-3 Inflammasome”, was published in Antioxidants & Redox Signaling. The paper discusses the emerging concept of redox-mediated inflammasome regulation.
Oct 25-28, 2023 SICEM 2023, Seoul/Korea
Dr. Yoshihara gave a talk entitled “Overcoming barriers in diabetes therapy: immune-evasion and mass production of stem cell-derived islets” in diabetes for the SICEM2023 (https://sicem.kr/about/welcome.php) in Seoul/Korea (On Site at Lotte Hotel World, Jamsil, Seoul).
Sep 14, 2023 TRDRP Research Award
Our lab receives the TRDRP research award for studying maternal inheritance of metabolic and e-cigarette exposures on pancreas and brain development. https://lundquist.org/news/lundquist-institute-investigator-eiji-yoshihara-phd-receives-two-major-grants-diabetes
Aug 1, 2023 JDRF multi-PI/multi-Institution grant
Our lab and our collaborators from City of Hope and University of Cincinnati receives a mulit-PI/multi-Institional research grant from JDRF. We will develop the novel transplantable bionanofiber materials to control oxygenation and immune response to improve the survival of stem cell derived pancreatic islets for cell therapy in diabetes.
May 4, 2023 Seminar in University of Tubingen, Germany
Dr. Yoshihara gave a talk about the stem cell based therapeutics in diabetes for the IDM in University of Tubingen, Germany.
Apr 27, 2023 News&Views in Nature Cell Biology
We published News&Views entitled “A guide from the stomach to β cells” in Nature Cell Biology (https://www.nature.com/articles/s41556-023-01140-w). We discussed recent findings of Huang et al, a novel technology to create gastric stem cells derived GINS organoids (https://www.nature.com/articles/s41556-023-01130-y).
March 4, 2023 7th Metabolic syndrome meeting-Univ Tokyo/Astellas
Dr. Yoshihara gave a talk about the stem cell based therapeutics in diabetes in the 7th Metabolic syndrome meeting hosted by University of Tokyo/Astellas at Tokyo, Japan.
Jan 11, 2023 Endocrine Grand Rounds seminar series at UCSD
Dr. Yoshihara gave a talk about new technology for engineering complex human organoids in the Endocrine Grand Rounds seminar series at University of California, San Diego (UCSD).
Oct 20, 2022 Islet research group seminar series
Dr. Yoshihara gave a talk about new technology for engineering complex human organoids in the islet research group seminar series hosted by Mayo Clinic/UCLA/City of Hope/Washington university/University of Montreal.
May 26, 2022 Beatson Foundation Grant
We are pleased to have received two-year Beatson Foundation Passion to Cure Grant 2022. The goal of the study, “Proliferative functional human islet like organoids” is to explore the technology development to achieve infinitely supply of functional human β cells. https://lundquist.org/news/lundquist-investigator-eiji-yoshihara-phd-receives-grant-explore-potential-new-pathway. https://www.beatsonfoundation.org/grant-recipients/
May 11, 2022 The 65th annual meeting of the japan diabetes society
Dr. Yoshihara gave a talk entitled “Functional maturation and immune protection of human islet-like organoids” in the 65th annual meeting of the japan diabetes society. https://site.convention.co.jp/65jds/overseas/
May 9, 2022 Seminar series at KAIST
Dr. Yoshihara gave a talk entitled “Functional maturation and immune protection of human islet-like organoids” in KAIST (Korea) for their first year graduate students.
May 4, 2022 Our review paper about type 2 diabetes is published in IJMS
Our review article entitled "Stem Cell-Derived Islets for Type 2 Diabetes" is published in International Journal of Molecular Sciences. https://www.mdpi.com/1422-0067/23/9/5099. We discussed the utility of human pluripotent stem cell-derived islets to study and treatment of type 2 diabetes.
Apr 25, 2022 Our perspective article is published in Frontiers in Cell and Developmental Biology
Our perspective article entitled “Adapting physiology in Functional Human islet Organogenesis” is published in Frontiers in Cell and Developmental Biology. https://www.frontiersin.org/articles/10.3389/fcell.2022.854604/full. We discussed perspective view of in vitro functional maturation of generated human islets and it’s missing cues.
Apr 21, 2022 Research Article-Gastroenterology
We and our colleagues at KAIST and Salk Institute’s latest study identified estrogen-related receptor γ (ERRγ), a master transcriptional factor for mitochondrial metabolic regulation links metabolic dysfunction to lead acute pancreatitis. Pancreatitis is the leading cause of pancreatic cancer or autoimmune diabetes, therefore this finding provide the better understanding of the pathogenesis of pancreatic diseases. The research finding was published in Gastroenterology. DOI:https://doi.org/10.1053/j.gastro.2022.04.013
March 15, 2022 JDRF Career Development Award
Dr.Yoshihara has received a five-year Career Development Award from JDRF (https://www.jdrf.org/) for his proposed study on how human β cells gain immune evasive function by environmental cues. https://www.prnewswire.com/news-releases/lundquist-institute-investigator-eiji-yoshihara-phd-receives-internationally-prestigious-award-for-research-on-type-1-diabetes-301503788.html.
Nov 3, 2021 The 94th Annual Meeting of the Japanese Biochemical Society
Dr. Yoshihara organized the session "State-of-the-art biotechnologies for biomedical innovation" (2S03m) at The 94th Annual Meeting of the Japanese Biochemical Society. https://www2.aeplan.co.jp/jbs2021/en/program.html#2S03m. We discussed current advances on stem cells, genome engineering and genomics for biomedical innovation.
Sep 12, 2021 Our latest review paper is published in Frontiers in Endocrinology
Our comprehensive review paper entitled “Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes” is published in Frontiers in Endocrinology. https://www.frontiersin.org/articles/10.3389/fendo.2021.732431/full
We have discussed current challenges for the site specific islet transplantation therapy.
Aug 10, 2021 Our review paper is published in Frontiers in Endocrinology
Our comprehensive review paper entitled “Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes” is published in Frontiers in Endocrinology. https://www.frontiersin.org/articles/10.3389/fendo.2021.716625/full
We have discussed state-of-the-art technologies of stem cell based cell therapy in diabetes and the way to protect the transplanted cells from allogenic and autoimmune rejection.
July 20, 2021 Allen Foundation Grant
We are grateful for the support from the Allen Foundation https://www.allenfoundation.org/ for our study entitled “Regulation of hormone secretion in human islet-like organoids derived from pluripotent stem cells”. This grant will support our work on stem cell based therapy in diabetes!
July 19, 2021 Research highlight in Japanese medical magazine
Yoshihara lab’s research activity is highlighted in the Japanese medical magazine-Experimental Medicine/Jikken-Igaku/実験医学 (Yodosya/羊土社) https://www.yodosha.co.jp/jikkenigaku/book/9784758125468/ (Japanese only)
July 6, 2021 Seminar series at KAIST-GSMSE & KU-IRCMS
Dr. Yoshihara gave a talk entitled “Engineering islet organoids for immune evasion” in the KAIST (Korea)-Kumamoto University (Japan) Joint Invited Speaker Seminar Series for Future Medicine. https://ircms.kumamoto-u.ac.jp/seminars/2021/07/july-7-joint-invited-speaker-seminar-for-future-medicine.html
June 17, 2021 Milestone-Diabetes/Nature Medicine
Dr.Yoshihara’s work is selected in the special collection of Milestone/Diabetes in Nature Medicine. Free to access for 6 month. https://www.nature.com/collections/aecjgdhadg
June 16, 2021 CTSI UCLA Core Voucher Award 2021
Yoshihara laboratory is awarded for the CTSI UCLA Core Voucher Award 2021! This grant will help to cover the cost of Core Facilities in UCLA.
June 2, 2021 Heterogeneity of Diabetes: Beta Cells, Phenotypes and Precise Medicine by CHIR-NIH
Dr. Yoshihara gave a talk entitled “Engineering islet organoids for immune evasion” in the Symposium organized by Canadian Institutes of Health Research, Institute of Nutrition and Metabolism and Diabetes (CIHR-INMD) and National Institute of diabetes and Digestion and Kidney Diseases (NIH-NIDDK). Dr. Yoshihara also joined the discussion about the future perspective for regenerative medicine in diabetes as panelist. https://www.niddk.nih.gov/news/meetings-workshops/2021/heterogeneity-diabetes-beta-cells-phenotypes-precision-medicine?agenda
May 28, 2021 Japanese book chapter-Diabetes 2021 (Igakusyo-syuppan)
Dr. Yoshihara’s latest book chapter about Developmental biology in Diabetes is published in Diabetes2021/tounyoubyou-gaku2021/糖尿病学2021 (Igakusyo-syuppan/医学書出版) http://shindan.co.jp/books/index.php?menu=10&cd=250700&kbn=1 (Japanese only)
Apr 20, 2021 Podcast Talk in The Sugar Science
Dr. Yoshihara joined The Sugar Science to discuss the research taking place at Yoshihara Laboratory and answer the question regarding current state-of-the-art technologies in the field of stem cells and diabetes. https://www.podbean.com/media/share/pb-tba2j-1013ce6?utm_campaign=w_share_ep&utm_medium=dlink&utm_source=w_share
March 25, 2021 The 12th Annual StemCellTalks Symposium at the University of Toronto
Dr. Yoshihara gava a talk entitled “An Approach Treating Type 1 Diabetes” in the 12th Annual StemCellTalks Symposium hosted by the University of Toronto. https://lts.escalator.utoronto.ca/home/stem-cell-talks/
March 3, 2021 Lundquist Institute Seeds Grant
Yoshihara laboratory is awarded for the Lundquist Institute Seeds Grant. This grant will help to cover the cost of high risk, high reward pilot study.
Dec 18, 2020 Japanese book chapter-Experimental Medicine (Yodosya)
Dr. Yoshihara’s latest book chapter about Stem Cell Therapy in Diabetes is published in Experimental Medicine/Jikken-Igaku/実験医学 (Yodosya/羊土社) https://www.yodosha.co.jp/jikkenigaku/book/9784758125390/index.html (Japanese only)
Dec 2, 2020 Biology at true resolution: Resolve biological complexities with single cell and spatial solutions (Hosted by 10X Genomics)
Dr. Yoshihara gave a talk entitled “WNT4-ERRgamma Axis in Functional Human Islet Organogenesis” in the symposium hosted by 10X genomics.
Nov 12, 2020 CIRM Grant
We are grateful for the support from the California Institute for Regenerative Medicine (CIRM) https://www.cirm.ca.gov/our-progress/awards/dual-angiogenic-and-immunomodulating-nanotechnology-subcutaneous-stem-cell. This grant will support our work on stem cell based therapy in diabetes! We collaborate with Dr. Lina R NIH’s lab for this project!
Nov 8, 2020 Topic Editor in Frontiers in Endocrinology
Dr. Yoshihara is assigned for the Topic Editor of “Frontiers in Endocrinology”. In this special collection, we aim to collect the studies relate to “Pancreatic Islets Cell Therapy: Immune protection and Advanced Technology”. https://www.frontiersin.org/research-topics/17318/pancreatic-islets-cell-therapy-immune-protection-and-advanced-technology
Oct 15, 2020 Seminar at Mayo Clinic , Arizona
Dr. Yoshihara gave a seminar entitled “Immune evasive human islet-like organoids ameliorate diabetes” for Mayo Clinic at Arizona.
Aug 19, 2020 Our paper is published in Nature
Our paper is published in Nature PMID: 30794774. We have elucidated the maturation pathway and immune evasive pathway of human islet organogenesis by using newly developed human pluripotent stem cells derived islet-like organoids technology.
This paper is highlighted in The New England Journal of Medicine (https://www.nejm.org/doi/full/10.1056/NEJMcibr2028410), Cell Stem Cell (https://doi.org/10.1016/j.stem.2020.09.008), Nature Reviews Endocrinology (https://www.nature.com/articles/s41574-020-00417-6), Science Translational Medicine (https://stm.sciencemag.org/content/12/559/eabe4433), and NIH Director’s Blog (https://directorsblog.nih.gov/2020/09/24/insulin-producing-organoids-hope-for-treating-type-1-diabetes/)
Aug 18, 2020 Our review paper is published in Antioxidants
Our comprehensive review paper for the decades of work related Thioredioxin Interacting Protein (TXNIP) is published in Antioxidants PMID: 32824669.
TXNIP is currently well recognized as one of most important diabetic target molecule which was originally identified as inhibitory/interacting protein of Thioredoxin, an anti-oxidants in 1999 at Kyoto University/Japan where the laboratory Dr. Yoshihara studied for his Ph.D.
Aug 3, 2020 Department of Endocrinology Vaucher Award
Yoshihara laboratory is awarded for the Department of Endocrinology at Lundquist Institute Voucher Award! This grant will help to cover the cost of high risk, high reward pilot study.
July 15, 2020 New member Joined lab!
Meghan Tahbaz joined lab!
July 1, 2020 Mishima Kaiun Memorial Foundation Research Award
Dr. Yoshihara is awarded Mishima Kaiun Memorial Foundation Research Award in Japan!
June 23, 2020 Integrated Islet Distribution Program (IIDP) Pilot Grant
Yoshihara laboratory is awarded for the Pilot grant under the islet award initiative of Integrated Islet Distribution Program (IIDP) entitled “Analysis of human islet organogenesis”.
May 13, 2020 CTSI UCLA Core Voucher Award 2020
Yoshihara laboratory is awarded for the CTSI UCLA Core Voucher Award 2020! This grant will help to cover the cost of Core Facilities in UCLA.
Apr 1, 2020 New Lab opened its door!
Yoshihara laboratory is launched at Lundquist Institute at Harbor-UCLA Medical Center.