PUBLICATIONS
2024
Choi J #, Cayabyab F #, Perez H and Yoshihara E* (#equally contribution/*Correspondence). Scaling Insulin-Producing Cells by Multiple Strategies. Endocrinology and Metabolism, 2024. https://www.e-enm.org/journal/view.php?doi=10.3803/EnM.2023.1910 Review
Yoshihara E*, Matsuo Y*, S Masaki*, Chen Z*, Tian H*, Masutani H*, Yamauchi A*, Hirota K*, Yodoi J* (*Co-correpondence). Redoxisome update:TRX and TXNIP/TBP2-dependent Regulation of NLRP-1/NLRP-3 Inflammasome. Antioxidants & Redox Signaling, 2024. https://www.liebertpub.com/doi/epdf/10.1089/ars.2024.0549 Editorial
2023
Choi J #, Cayabyab F # and Yoshihara E* (#equally contribution/*Correspondence). A guide from the stomach to β cells. Nature Cell Biology, 2023. https://www.nature.com/articles/s41556-023-01140-w News&Views
2022
Salib A, Cayabyab F and Yoshihara E* (*Correspondence). Stem cell-derived islets for Type 2 diabetes. International Journal of Molecular Sciences, 2022. https://www.mdpi.com/1422-0067/23/9/5099 Review
Yoshihara E* (*Correspondence). Adapting Physiology in Functional Human Islet Organogenesis. Frontiers in Cell and Developmental Biology, 2022. https://doi.org/10.3389/fcell.2022.854604 Perspective Review
Choi J, Oh TG, Jung HW, Park KY, Shin H, Jo T, Kang DS, Chanda D, Hong S, Kim J, Hwang H, Ji M, Jung M, Shoji T, Matsushima A, Paik MJ, Kim P, Mun JY, Cho SJ, Lee IK, Whitcomb DC, Greer P, Blobner B, Mark G, Pandol SJ, Rotter JI, Fan W, Bapat SP, Zheng Y, Liddle K, Yu RT, Atkins A, Downes M, Yoshihara E*, Evans RM*, and Suh JM*. (*co-correspondence). Estrogen-Related Receptor γ (ERRγ) maintains pancreatic acinar cell function and identity by regulating cellular metabolism. Gastroenterology, 2022. DOI:https://doi.org/10.1053/j.gastro.2022.04.013
2021
Cefalu WT, Andersen DK, Arreaza-Rubín G, Pin CL, Sato S, Verchere CB, Woo M, Rosenblum ND; Symposium planning committee, moderators, and speakers:, Rosenblum N, Cefalu W, Andersen DK, Arreaza-Rubín G, Dhara C, James SP, Makarchuk MJ, Pin CL, Sato S, Verchere B, Woo M, Powers A, Estall J, Hoesli C, Millman J, Linnemann A, Johnson J, Pin CL, Hawkins M, Woo M, Gloyn A, Cefalu W, Rosenblum N, Huising MO, Benninger RKP, Almaça J, Hull-Meichle RL, MacDonald P, Lynn F, Melero-Martin J, Yoshihara E, Stabler C, Sander M, Evans-Molina C, Engin F, Thompson P, Shalev A, Redondo MJ, Nadeau K, Bellin M, Udler MS, Dennis J, Dash S, Zhou W, Snyder M, Booth G, Butte A, Florez J. Heterogeneity of Diabetes: β-Cells, Phenotypes, and Precision Medicine: Proceedings of an International Symposium of the Canadian Institutes of Health Research's Institute of Nutrition, Metabolism and Diabetes and the U.S. National Institutes of Health's National Institute of Diabetes and Digestive and Kidney Diseases. Diabetes, 2021. PMID:34957490
Iwamoto M, Masuya T, Hosose M, Tagawa K, Ishibashi T, Yoshihara E, Downes M, Evans RM, Mastushima A. Bisphenol A derivatives act as novel coactivator binding inhibitors for estrogen receptor β. Journal of Biological Chemistry, 2021. PMID: 34499926
Cayabyab F, Nih LR and Yoshihara E* (*Correspondense). Advances in Pancreatic Islet Transplantation Sites for the Treatment of Diabetes. Frontiers in Endocrinology, 2021. PMID: 34589059 Review
Tahbaz M and Yoshihara E* (*Correspondence). Immune Protection of Stem Cell-Derived Islet Cell Therapy for Treating Diabetes. Frontiers in Endocrinology, 2021. PMID: 34447354 Review
2020
Yoshihara E* (*Correspondence). TXNIP/TBP-2, a master regulator for glucose homeostasis. Antioxidants, 2020. PMID: 32824669 Review
Yoshihara E, Connor CO, Gasser E, Wei Z, Oh TG, Tseng TW, Wang D, Cayabyab F, Dai Y, Yu RT, Liddle C, Atkins A, Downes M, Evans RM. Immune evasive human islet-like organoids ameliorate diabetes. Nature, 2020 https://doi.org/10.1038/s41586-020-2631-z. PMID: 32814902
2019
Fu T, Coulter S, Yoshihara E, Oh TG, Fang S, Cayabyab F, Zhu Q, Leblanc M, Gasser E, Liu S, Waizenegger W, He M, Atkins AR, Yu RT, Knight R, Liddle C, Downes M, Evans RM. FXR regulates intestinal cancer stem cell proliferation. Cell 176, 1098-1112, 2019. PMID: 30794774
2018
Wei Z, Yoshihara E, He N, Hah N, Fan W, Huddy T, Wang Y, Ross B, Dai Y, Ding N, Sherman MH, Fang S, Zhao X, Liddle C, Atkins AR, Yu RT, Downes M, Evans RM. Vitamin D switches BAF complexes to protect β cells. Cell 173, 1-15, 2018. PMID: 29754817
Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM. ERRγ preserves Brown Fat Innate Thermogenic Activity. Cell Reports 11, 2849-2859, 2018. PMID: 29539415
2016
Yoshihara E, Wei Z, Lin CS, Fang S, Ahmadian M, Kida Y, Tseng T, Dai Y, Yu RT, Liddle C, Atkins A, Downes M, Evans RM. ERRγ is required for the metabolic maturation of therapeutically functional glucose responsive β cells. Cell Metabolism 23, 1-13 2016. Best of Cell Metabolism 2016, PMID: 27076077
2015
Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Dowens M, Evans RM. Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance. Nature Medicine, doi: 10.1038/nm.3760, 2015. PMID: 25559344
Kida YS, Kawamura T, Wei Z, Sogo T, Jacinto S, Shigeno A, Kushige H, Yoshihara E, Liddle C, Ecker JR, Yu RT, Atkins AR, Downes M, Evans RM. ERRs Mediate a Metabolic Switch Required for Somatic Cell Reprogramming to Pluripotency. Cell Stem Cell, 6(5):547-55, 2015. PMID: 25865501
2014
Suh JM, Jonker JW, Ahmadian M, Goetz R, Lackey D, Osborn O, Huang Z, Liu W, Yoshihara E, Dijk TH, Havinga R, Fan W, Yin YQ, Yu RT, Liddle C, Atkins AR, Olefskey JM, Mohammadi M, Downes M, Evans RM. Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer. Nature, doi: 10.1038/nature13540, 2014. PMID: 25739500
Yoshihara E, Masaki S, Matsuo Y, Chen Z, Tien H, Yodoi J. Thioredoxin/Txnip; Redoxisome, as a Redox Switch for the Pathogenesis of Diseases. Front immunology, doi: 10.3389/fimmu.2013.00514, 2014. PMID: 24409188 Review
Takada H, Saito Y, Mituyam T, Wei Z, Yoshihara E, Jacinto S, Downes M, Evans RM, Kida YS. Methylome, transcriptome, and PPAR (γ) cistrome analyses reveal two epigenetic transitions in fat cells. Epigenetics, doi: 10.4161/epi.29856, 2014
~2013
Masaki S, Masutani H, Yoshihara E, Yodoi J. Deficiency of Thioredoxin binding protein-2 (TBP-2) enhances TGFβ signaling and promotes epithelial to mensenchymal transition. PLoS One, 2012; 7(6):e39900. doi: 10.1371/journal.pone.0039900
Masutani H, Yoshihara E, Masaki S, Yodoi J. Thioredoxin binding protein (TBP)-2/Txnip and α-arrestin proteins in cancer and diabetes mellitus. Journal of Clinical Biochemistry and Nutrition. 2012 Jan;50(1):23-34. PMID:22247597
Chen Z, Lopez-Ramos DA, Yoshihara E, Maeda Y, Masutani H, Sugie K, Maeda M, Yodoi J. Thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) regulates T cell sensitivity to glucocorticoid during HTLV-I-induced transformation. Leukemia, 2011, doi:10.1038/leu.2010.286
Oka SI, Liu W, Yoshihara E, Ahsan K, Lopez-Ramos DA, Son A, Okuyama H, Zhang L, Masutani H, Nakamura H, Yodoi J. Thioredoxin binding protein-2 mediates metabolic adaptation in response to lipopolysaccaride in vivo. Critical Care Medicine, 38(12):2345-51, 2010
Masters SL, Dunne A, Subramanian SL, Hull RL,Tannahill GM, Sharp FA, Becker C, Franchi L, Yoshihara E, Chen Z, Mullooly N, Mielke LA, Harris J, Coll R, Mills KHG, Mok KH, Newsholme P, Nunez G, Yodoi J, Kahn SE, Lavelle EC, O’Neill LA. Activation of the Nlrp3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type-2 diabetes. Nature Immunology, 11(10): 897-904, 2010. PMID: 20835230
Yoshihara E, Fujimoto S, Inagaki N, Okawa K, Masaki S, Yodoi J, Masutani H. Disruption of TBP-2 ameliorates insulin sensitivity and secretion without affecting obesity. Nature Communications, 1:127 doi: 10.1038/ncomms1127, 2010. PMID: 21119640
Yoshihara E, Chen Z, Matsuo Y, Yodoi J, Masutani H. Thiol Redox Regulation by Thioredoxin and Thioredoxin Binding Protein-2 in Cell Signaling. Methods in Enzymology, Volume 474, pp76-82, 2010 Review
Chen Z, Yoshihara E, Son A, Matsuo Y, Masutani H, Sugie K, Maeda M, Yodoi J. Differential roles of Annexin A1 (ANXA1/lipocortin-1/lipomodulin) and thioredoxin binding protein-2 (TBP-2/VDUP1/TXNIP) in mediating glucocorticoid responses of T cells transformed by HTLV-1. Immunology letters, 15;131(1):pp11-18, 2010
Oka SI#, Yoshihara E#, Bizen-Abe A, Liu W, Watanabe M, Yodoi J, Masutani H. (#equally 1st author) Thioredoxin Binding Protein-2/Thioredoxin Interacting Protein is a Critical Regulator of Insulin Secretion and Peroxisome Proliferator Activated Receptor Function. Endocrinology, 150(3), pp1125-1234, 2008
Son A, Nakamura H, Okuyama H, Oka SI, Yoshihara E, Liu W, Matsuo M, Kondo N, Masutani H, Ishii Y, Iyoda T, Inaba K, Yodoi J. Dendritic cells derived from thioredoxin binding protein-2 deficient mice are defective to induce T cell response. European Journal of Immunology, Volume 38 Issue 5, pp1358-1367, 2008